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February 1965

Oral Sodium Tolbutamide And Glucose Tolerance Tests

Author Affiliations


From the Upjohn Company.

Arch Intern Med. 1965;115(2):161-166. doi:10.1001/archinte.1965.03860140041009

AN ORAL MODIFICATION of the intravenous tolbutamide test originally devised by Unger and Madison 1 has been described by Boshell,2 and tentative criteria for the diagnosis of diabetes established in presumed normal and known diabetic subjects. This test, in which 2.0 gm of sodium tolbutamide are administered orally in rapidly dissolving tablets along with sodium bicarbonate, gave results comparable to the intravenous test with a lag of about ten minutes.2,3 The upper limit of normal for the 30-minute blood glucose specimen was found to be 78% of the pretest value. Individual agreement of this test with the oral glucose tolerance test was generally good regarding diagnostic classification, though with some conflicts. Reproducibility was good except in borderline subjects.3

In order to establish normal baselines for the test, and to study the influence of age, body weight, and absorption of sodium tolbutamide on the results, we have performed