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February 1965

Use of Fluoridated Water in Long-Term Hemodialysis

Author Affiliations


From the Department of Radiation Biology, and the Department of Pathology, University of Rochester School of Medicine and Dentistry. Assistant Professor, Radiation Biology (Dr. Taves); Professor of Pathology (Dr. Terry); Associate Professor of Radiation Biology (Toxicology) (Dr. Smith); Technical Associate (Dr. Gardner).

Arch Intern Med. 1965;115(2):167-172. doi:10.1001/archinte.1965.03860140047010

THE FLUORIDE concentration in fluoridated water (1 ppm) is normally about six times that in serum. Therefore, when such water is used in the dialysate bath of an artificial kidney, fluoride ions would be expected to move into the patient's blood. How much of the fluoride is absorbed from the dialysate has not been reported, but the volume of the dialysate would generally be at least 200 liters, representing 200 mg of fluoride. The amount absorbed would depend at least in part on the average concentrations of fluoride in the serum during dialysis. This is a report of the absorption of fluoride by a patient with chronic renal insufficiency who underwent dialysis repeatedly with fluoridated water in the dialysate bath.

Report of Case  The patient was a 41-year-old nurse who had had proteinuria for over 20 years, hypertension for 11 years subsequent to a pregnancy, and periodic urinary tract