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February 1965

Malignant Lymphoma As Cause of Midline Granuloma

Author Affiliations


From the Department of Medicine, University of Florida College of Medicine. Intern in Medicine.

Arch Intern Med. 1965;115(2):200-202. doi:10.1001/archinte.1965.03860140080018

SINCE THE FIRST description by McBride 1 in 1897 there have been many conditions described as midline granuloma. There are now more than 100 cases published in the literature. Klinger2 in 1931 described a type of midline granuloma with multiple system involvement, and after Wegener's 3 description of three similar patients in 1936, it became apparent that this was a different disorder from lethal midline granuloma. This syndrome has since been called Wegener's granulomatosis.

Several other diseases may present with the symptomatology of midline granuloma and lead to an erroneous diagnosis. This case is reported because of the unusual appearance of a lymphoma with symptomatology suggestive of midline granuloma and to call attention to an unusual cause of this entity.

Report of a Case  A 49-year-old white man was admitted to the University of Florida Teaching Hospital on Sept 10, 1963, with an illness of eight months' duration. Initially