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February 1965

Sjögren's Syndrome and Lupus Erythematosus: A Case Report

Author Affiliations


From the Department of Medicine, Norfolk General Hospital.

Arch Intern Med. 1965;115(2):235-238. doi:10.1001/archinte.1965.03860140115024

THE SYNDROME of Henrick Sjögren was classically described by him in 1933,1 when he published the case records of 19 patients presenting inflammation of the cornea and conjunctiva associated with dryness (keratoconjunctivitis sicca), diminished salivary and laryngeal gland secretion (xerostomia), and associated arthritis.

The principal clinical manifestations of this syndrome, as originally described, were dryness of the eyes, with lack of or diminution of tearing, but rarely lacrimal gland enlargement; dryness of the mouth, with associated parotid gland enlargement; and polyarthritis of the rheumatoid type. In adition, other signs, symptoms, and clinical features were often, but not always, seen including acrodermatitis, purpura, alopecia, achylia, Raynaud's phenomenon, dry atrophic vaginitis, and pernicious anemia.2 Sjögren pointed out originally,2 however, that one or two of the initial triad of symptoms may be lacking in a given case.

Since the original description, additional features have been reported as occurring in or