IT HAS been reported that 1-methyl-Δ1-androstenolone administered as the acetate per os or as the enanthate by injection together with digitoxin improves skeletal muscle performance or retards loss of muscle strength in muscular dystrophy and related myopathies in man and in dystrophic mice.1,2 Our findings in 21 patients with muscular dystrophy treated with these agents are herein described.
Materials and Methods
The two steroids cited above were administered according to Dowben's program 2 for five to seven months or longer to a total of 21 patients with muscular dystrophy of childhood, teenage, or young adult onset. Ten of the patients received 20 mg of 1-methyl-Δ1-androstenolone acetate by mouth each day. In the other 11 patients 1-methyl-Δ1-androstenolone (2.0 mg per kilogram of body weight) was injected as the enanthate in sesame oil every two weeks.* Both groups received digitoxin, 0.2 to 0.7 mg per
DANOWSKI TS, SABEH G, VESTER JW, SARVER ME, SUNDER JH. Muscular Dystrophy: XI. Trials of 1-Methyl-?1-Androstenolone and Digitoxin. Arch Intern Med. 1965;115(3):294–301. doi:10.1001/archinte.1965.03860150038007
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