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March 1965

Effects of Sarcoid On the Lungs

Author Affiliations


Read before the Section on Internal Medicine, 113th Annual Meeting, American Medical Association, San Francisco, Calif, June 23, 1964.; From the Pulmonary Function Laboratory, City of Detroit Receiving Hospital and departments of medicine and radiology, Wayne State University. Dr. Martin is now at Mather AFB, California.

Arch Intern Med. 1965;115(3):330-335. doi:10.1001/archinte.1965.03860150074014

WHAT are the consequences of a pulmonary parenchymal lesion due to sarcoid? The question is not answered definitively from large series of patients, for example, that of Hoyle and Smellie,1 followed clinically and radiologically for extended periods, since Marshall and co-workers 2 found functional abnormalities in five of six of these patients whose x-ray had cleared. For the same reason the careful physiological studies of Svanborg3 on patients with radiologic "fibrosis" are not a full answer. It seemed to us worthwhile, therefore, to study patients in whom duration of disease rather than radiologic appearance was the criterion for investigation and to report clinical, radiologic, and functional findings in ten patients five or more years after the onset of parenchymal lesions due to sarcoid.

Materials and Methods  Between 1956 and 1963, 34 patients in whom a diagnosis of sarcoid was made on clinical grounds and substantiated by biopsy