[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
May 1965

Spontaneous Rupture of The Spleen in Hemophilia

Author Affiliations


From the Hematology Section of the Medical Service of the Veterans Administration Hospital. Chief, Hematology Section, Veterans Administration Hospital; Assistant Clinical Professor of Medicine, University of Southern California School of Medicine, Los Angeles (Dr. Brook); Chief Resident, Medical Service, Veterans Administration Hospital (Dr. Newnam).

Arch Intern Med. 1965;115(5):595-597. doi:10.1001/archinte.1960.03860170077016

THE HEMOPHILIAC patient is prone to develop severe complications from minor trauma. Despite this, traumatic rupture of the spleen in hemophilia has only been noted in three previous reports.1-3 We recently treated a hemophiliac patient for spontaneous rupture of the spleen, and the uniqueness of this case prompted us to review the literature. We believe that this is the first reported case of spontaneous splenic rupture in hemophilia. Although splenectomy was uneventful and bleeding was controlled, the patient died from circulatory overload, a complication of transfusion therapy.

Report of a Case  A 41-year-old white man was admitted to the hospital with abdominal pain, nausea, and vomiting of five days' duration. During the week prior to admission, he and other members of his family had rhinorrhea, cough, nausea, vomiting, and low-grade fever. He had not been in an automobile accident, nor had he been struck in the abdomen. There had