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June 1965

Coexisting Sarcoidosis and Cryptococcosis

Author Affiliations


From the Pulmonary Disease Division, Department of Medicine, University of Tennessee, and the West Tennessee Tuberculosis Hospital. Instructors in medicine (Drs. Harris and Blumenfeld); Assistant Professor of Pathology (Dr. Cruthirds); Associate Professor of Medicine (Dr. McCall); University of Tennessee.

Arch Intern Med. 1965;115(6):637-643. doi:10.1001/archinte.1960.03860180009002

THE coexistence of cryptococcosis and malignant disease of the reticuloendothelial system is well known. Up to 30% of cases of cryptococcosis have been reported to be associated with Hodgkin's disease, lymphosarcoma, or leukemia.1,2 Other conditions reported to frequently be associated with cryptococcal infection include tuberculosis,3-6 diabetes,5,7 sarcoidosis,7-18 and steroid therapy.19-21 Indeed, 50% of the 30 patients with cryptococcal meningitis reported by Spickard et al 7 had a coexisting disease. Although cryptococcosis is said to be more likely to occur in the presence of sarcoidosis,22 we have found only nine 8-18 such cases described in detail, and two others7 are mentioned briefly. There are several other patients who had cryptococcosis and in whom a typical sarcoid reaction was present without adequate evidence for the diagnosis of both diseases.23-25

The following case is the 12th reported documented one of coexisting cryptococcosis and sarcoidosis.

Report of a Case  A 29-year-old Negro woman was