[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
June 1965

Remediable Hypertension Due to Unilateral Renal Disease: Correlation of Split Renal-Function Tests and Pressor Assays of Renal Venous Blood in Hypertensive Patients

Author Affiliations


From the departments of medicine, surgery, and urology of the Wilford Hall USAF Hospital, Aerospace Medical Division (AFSC). Present address: Department of Surgery, University of Kentucky, School of Medicine, Lexington (Dr. Malette); Professor and Chairman of the Department of Experimental Medicine, University of Texas Southwestern Medical School, Dallas (Dr. Grollman).

Arch Intern Med. 1965;115(6):644-651. doi:10.1001/archinte.1960.03860180016003

ALTHOUGH several procedures have been recommended for the detection of patients suffering from correctable renal hypertension, none has proved to be adequate for the purpose, and the decision to undertake surgical intervention is based frequently on an educated guess. Stenosis of the renal artery remains the most commonly accepted indication of the possible presence of surgically remediable hypertension.1-13 However, this lesion is encountered frequently in normotensive patients14 and its repair is often not followed by reduction of the elevated blood pressure. Another commonly used diagnostic procedure for detecting correctable renal hypertension utilizes the decreased volume and sodium content of the urine of the affected kidney, as described first by Connor et al 1,2 and modified by Dustan et al,3 Stamey et al,13 Rapaport,15 Birchall et al,16 and others. This procedure likewise has failed to provide a decisive method for detecting patients with unilateral renal disease. The histological appearance of the