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June 1965

Renal Lesions in Hepatic Disease: A Study Based on Kidney Biopsies

Author Affiliations


From the Department of Medicine, New York Medical College and the Department of Pathology, Mount Sinai Hospital. Associate Clinical Professor of Medicine, New York Medical College, and Associate Visiting Physician, Flower and 5th Ave and Metropolitan hospitals (Dr. Salomon); Research Fellow in Pathology, Mount Sinai Hospital, and Associate Professor of Pathology, Keio University, Tokyo (Dr. Sakaguchi); Associate attending pathologists (Drs. Churg and Mautner); Research Fellow in Pathology and US Public Health Service postdoctoral trainee in pathology (2G-115) (Dr. Dachs); Research Associate in Pathology (Dr. Grishman); Assistant Attending Pathologist, Mount Sinai Hospital. (Dr. Paronetto); Assistant Professor of Medicine (Section of Gastroenterology), New York Medical College (Dr. Rosenthal).

Arch Intern Med. 1965;115(6):704-709. doi:10.1001/archinte.1960.03860180076013

THE IMPACT of liver disease upon the function of the kidney was first described in 1863 by Austin Flint1 who noted the presence of oliguria in patients with cirrhosis. This finding was confirmed in 1901 by Gilbert and Lereboullet.1 In recent years a considerable body of literature has accrued dealing with the physiologic and clinical significance of renal involvement in liver disease. Many of these studies have been reviewed by Popper and Schaffner,2 Eisner and Levitt,3 and by Papper.4 Some authors have implicated the kidney in the development of hepatic ascites and edema by pointing out disturbances in glomerular filtration rate, proximal tubular reabsorption, and renal blood flow.5

Little emphasis, however, has been placed on morphologic alterations. Indeed, structural changes of the kidney in cirrhosis, when described, were concerned mainly with the more obvious tubular findings. Glomerular changes were first noted by Baxter and Ashworth6 who described periglomerular