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July 1965

Hypogammaglobulinemia With Chronic Bronchitis or Bronchiectasis: Treatment of Five Patients With Long-Term Antibiotic Therapy

Author Affiliations


From the University of Illinois Research and Educational Hospitals, the Department of Medicine, University of Illinois. Professor of Medicine and Head of Department: (Dr. Dowling); Professor of Medicine (Dr. Jackson). Formerly US Public Health Service Fellow in Infectious Diseases, University of Illinois College of Medicine, Department of Medicine (Dr. Suhs).

Arch Intern Med. 1965;116(1):29-38. doi:10.1001/archinte.1965.03870010031006

ACQUIRED hypogammaglobulinemia is characterized by frequent respiratory-tract infections and may be associated with chronic infection of the bronchial tree. Continuous therapy with γ-globulin, sulfonamides, or antibiotics has been advocated for the prevention of acute exacerbations of bronchial infection. In this paper five patients with acquired hypogammaglobulinemia, given antibiotics as prophylactics, are reported and other adequately documented cases that have been reported are reviewed.

Method of Study  Our five patients1 are part of a larger group observed in a long-term study of chronic bronchitis and bronchiectasis to determine whether the continuous administration of certain antibiotics would diminish bacterial infections and retard the progress of the disease. Among 155 patients examined, four were found to have hypogammaglobulinemia.2 Each of these patients was started on a different therapeutic regimen, which was later changed if necessary. These will be described in detail later. One additional patient (patient 5) with hypogammaglobulinemia was