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September 1965

Pseudomonas Infection: Treatment With Immune Human Plasma

Author Affiliations


From the departments of research medicine and pediatrics, University of Pennsylvania School of Medicine, Philadelphia. Instructor, Department of Research Medicine and presently at Beth Israel Hospital, Boston (Dr. Feingold) and Associate, Department of Pediatrics, (Dr. Oski).

Arch Intern Med. 1965;116(3):326-328. doi:10.1001/archinte.1965.03870030006002

Infections NFECTIONS with organisms of the genus Pseudomonas have become a serious nosocomial problem.1 These bacteria are frequently resistant to antimicrobial drugs. The treatment of these infections with commercial pooled γ-globulin (Cohn fraction II) has had, at best, limited success. In this report of a case, evidence is presented which suggests that plasma from a patient convalescing from a Pseudomonas infection may constitute effective therapy. The possible basis for the efficacy of such therapy is discussed.

Report of Case  A 5-year-old Caucasian boy was admitted to the Hospital of the University of Pennsylvania for the first time on Oct 29, 1963 with a two day history of vomiting, shaking chills, and fever. The patient had had aplastic anemia of unknown etiology for the previous six months. He had been treated for the past five months with testosterone propionate and prednisone. On this hormonal therapy the patient had shown