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October 1965


Arch Intern Med. 1965;116(4):490. doi:10.1001/archinte.1965.03870040004002

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In the article "20, 25-Diazacholestenol Dihydrochloride" by Sachs and Wolfman published in the September issue of the Archives, the following Summary was inadvertently omitted from page 372.

Summary  The structural analog of cholesterol, 20, 25-diazacholestenol dihydrochloride is a potent inhibitor of cholesterol biosynthesis in animals. The compound was found to produce a moderate decrease in plasma total sterol while effectively lowering the plasma cholesterol levels in a prolonged study as long as 92 weeks in 13 hypercholesterolemic patients. The compound had a marked triglyceride lowering effect in hypertriglyceridemic but not in normotriglyceridemic subjects. Associated with the fall of plasma cholesterol levels was the progressive accumulation of a precursor sterol identified as desmosterol. Inhibition in at least two sites in the cholesterol biosynthetic pathway must be present to explain the findings. Administration of the drug intermittently instead of continually resulted in further decreases in serum cholesterol values without further increases in

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