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Article
October 1965

Experimental Rubella: Clinical and Laboratory Findings

Author Affiliations

BETHESDA, MD

From the National Institutes of Health, Bethesda, Md. Head, Unit on Tissue Culture Investigations, Section on Infectious Diseases, Perinatal Research Branch, National Institute of Neurological Diseases and Blindness and presently Assistant Professor of Medicine and Microbiology, College of Medicine, University of Cincinnati, Cincinnati (Dr. Schiff); Head, Section on Infectious Diseases, Perinatal Research Branch, National Institute of Neurological Diseases and Blindness (Dr. Sever); Chief, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases (Dr. Huebner).

Arch Intern Med. 1965;116(4):537-543. doi:10.1001/archinte.1965.03870040051011
Abstract

SINCE the initial observations of Gregg,1 the adverse effects resulting from maternal rubella infection during the early part of pregnancy have been well recognized. Although rubella has been assumed to be of viral etiology, it was not until recently that the isolation of the virus in tissue culture and the detection of neutralizing antibody in patients was described.2-4 With the availability of these methods, it has become possible to conduct detailed studies correlating the laboratory findings with the clinical course of experimentally produced disease. Studies of this type can provide a better understanding of the disease, and hence a more intelligent approach to the prophylaxis, and perhaps eventually the control of the disease. The present investigation describes the clinical and laboratory findings for young adults following experimental intranasal infection with tissue culture grown rubella virus.

Materials and Methods  This investigation was undertaken as part of three volunteer studies

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