SINCE the initial observations of Gregg,1 the adverse effects resulting from maternal rubella infection during the early part of pregnancy have been well recognized. Although rubella has been assumed to be of viral etiology, it was not until recently that the isolation of the virus in tissue culture and the detection of neutralizing antibody in patients was described.2-4 With the availability of these methods, it has become possible to conduct detailed studies correlating the laboratory findings with the clinical course of experimentally produced disease. Studies of this type can provide a better understanding of the disease, and hence a more intelligent approach to the prophylaxis, and perhaps eventually the control of the disease. The present investigation describes the clinical and laboratory findings for young adults following experimental intranasal infection with tissue culture grown rubella virus.
Materials and Methods
This investigation was undertaken as part of three volunteer studies
SCHIFF GM, SEVER JL, HUEBNER RJ. Experimental Rubella: Clinical and Laboratory Findings. Arch Intern Med. 1965;116(4):537–543. doi:10.1001/archinte.1965.03870040051011
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