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October 1965

Cytomegalovirus Infection After Renal Transplantation

Author Affiliations


From the Department of Medicine, University of Colorado School of Medicine. Assistant Professor.

Arch Intern Med. 1965;116(4):554-558. doi:10.1001/archinte.1965.03870040068014

CHARACTERISTIC basophilic intranuclear inclusion body-containing cells morphologically compatible with viral infection were observed in autopsy lung specimens from 15 of 32 patients treated at this center by means of organ transplantation.1 These inclusions have been demonstrated in the brains of two patients and in an additional ten cases other histologic evidence of viral CNS infection was present.2 In three patients the inclusion body-containing cells were also disseminated to the lymph nodes, liver, pancreas, parathyroid, and salivary glands.1 In addition, a segment of donor ureter resected 228 days posttransplant because of stricture also contained these inclusions.3

It is the purpose of this communication to report the isolation and identification of a viral agent from the lungs of three patients who died following renal homotransplantation.


Tissue Culture.  —Specimens of lung obtained at autopsy were ground to approximately a 10% suspension in tissue culture medium. This consisted of Eagle's minimal essential medium