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December 1965

Absent Lamina Dura Associated With a Developmental Dentin Abnormality: A Family Study

Author Affiliations


From the School of Medicine and the School of Dentistry, West Virginia University, Morgantown. Professor and Chairman of Department of Oral Diagnosis, School of Dentistry (Dr. Graham); Assistant Professor of Medicine and Chairman of Hematology, School of Medicine (Dr. Harley); Assistant Professor of Oral Diagnosis, Division of Roentgenology, School of Dentistry (Dr. Alberico); and Associate Professor of Oral Pathology, School of Dentistry (Dr. Kelln).

Arch Intern Med. 1965;116(6):837-841. doi:10.1001/archinte.1965.03870060035008

IT IS OUR purpose to report a family study of an undescribed clinical entity of a dentin abnormality associated with absence of lamina dura which superficially resembled hyperparathyroidism. It is usually considered that the loss of the lamina dura is pathognomonic of hyperparathyroidism although some degree of loss may be apparent in osteomalacia and in Paget's disease.1 We have recently had the opportunity to observe a father and son with generally absent lamina dura, periapical osteolytic lesions of the jaw, indistinct trabecular pattern of the mandible, calcification of the root canals, minimal opalescent dentin, and abnormal morphology of the root dentin. A second son, age eight, presented a classical gross appearance of opalescent dentin; however, there was no evidence of attrition, and both root canals and lamina dura were normal. Evaluation of the mother and two sisters revealed no dental abnormalities.

Dental roentgenography may suggest hyperparathyroidism by the following: