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February 1966

Thrombotic Thrombocytopenic PurpuraRecovery After Splenectomy

Arch Intern Med. 1966;117(2):284-286. doi:10.1001/archinte.1966.03870080128022

This SYNDROME was first described by Moschcowitz in 1925 1 as an acute, febrile pleomorphic anemia with hyaline thrombosis of terminal arterioles and capillaries. Since then over 150 cases have been described. The predominant features are thrombocytopenia, hemolytic anemia, transient mental and focal neurological phenomena, pyrexia, and a variable degree of renal involvement. A leukocytosis is also frequently present, but leukopenia has been reported.2,3

The present case is reported because a dramatic recovery followed splenectomy after massive steroid therapy and repeated blood transfusion had failed to alter the downhill course of the disease.

Report of Case  Before this patient, a man 28 years old, presented with his acute illness, he had complained of tiredness and lethargy for about 12 months. The acute illness was heralded by a shivering attack. This was followed by increasing weakness and pallor with periods of confusion, and after five days the urine output fell,

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