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March 1966

Excretion Studies in Ethchlorvynol (Placidyl) Intoxication

Arch Intern Med. 1966;117(3):409-411. doi:10.1001/archinte.1966.03870090093017

DESPITE widespread use of ethchlorvynol as a sedative, there is a paucity of published information regarding the metabolism and mode of excretion of this drug. Without this basic information, treatment of overdosage must be based on unsatisfactory empirical grounds. We have recently studied the output of ethchlorvynol in the urine and in the dialysis fluid of an acutely intoxicated young woman, and should like to report these data.

Report of Case  A 32-year-old white woman was found comatose and taken to the nearest hospital approximately seven hours after the ingestion of 20 to 25 gm of ethchlorvynol. Gastric lavage yielded no formed material. Five hours later she was transferred to Arkansas Baptist Hospital.On admission, the patient's blood pressure was 80/40 mm Hg, the pulse rate 56 beats per minute, respiratory rate 28 per minute, and the rectal temperature 94.4 F (34.6 C). The patient was in coma, unresponsive