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April 1966

Experimental Histotoxic Nephritis.

Arch Intern Med. 1966;117(4):606. doi:10.1001/archinte.1966.03870100134041

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Dr. Paunz has incorporated into this volume a review of immunology and renal disease, his experimental techniques for producing histotoxic nephritis, and a discussion of pathogenesis of renal diseases. The book is divided into seven chapters: a historical survey, techniques, pathogenesis, the nephrosis syndrome, nephritis, therapeutic experiments, and nephro-omentopexy.

The author has described in this book many experiments on animals, mostly rabbits and occasionally dogs, in which a nephrotoxic serum is produced with whole kidney as the antigen. The serum contains several toxic antibodies, three in particular. The first antibody is described as fibrotoxic produced by the basement membrane of the glomerular loops acting as the antigen. This antibody produces a lesion primarily involving the basement membranes and vascular walls. The second toxic antibody is induced by antigenic substances from the renal epithelial cells and he refers to this as a nephroepithelial toxic antibody which produces lesions of the epithelial

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