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September 1966

Hypogammaglobulinemia in Hodgkin's Disease Treated With Nitrogen Mustard

Author Affiliations


From the Department of Medicine, University of Cincinnati College of Medicine, and the Medical Service, Hematology Section, Cincinnati Veterans Administration Hospital.

Arch Intern Med. 1966;118(3):199-202. doi:10.1001/archinte.1966.00290150013004

HODGKIN'S disease is associated only rarely with hypogammaglobulinemia.1-4 In 53 patients at the Cincinnati Veterans Administration Hospital with Hodgkin's disease, in whom serum protein electrophoresis was performed, only one had significant hypogammaglobulinemia. This report presents the single case with documentation of the quantitative serum protein abnormalities and the heretofore unreported return to normal following nitrogen mustard therapy.

Report of a Case  A 35-year-old Negro man was admitted to the Cincinnati Veterans Administration Hospital in May 1964 with a three-month history of lower abdominal cramping pain and right upper quadrant post prandial discomfort, together with anorexia and weight loss approximating 27 lb (12.2 kg). For the preceding six weeks there had been intermittent dark urine and temperature spikes to 104 F (40.0 C) which had not responded to aspirin and antibiotic therapy. There had been no known exposure to hepatoxins, recent injections or blood transfusions, and no known contact with

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