THE HE CURRENT medical literature reflects an increasing recognition of druginduced renal disease.1 The clinical effectiveness of the antibiotic, colistin, in a variety of bacterial infections has been well established.2-8 To date, disturbances of kidney function attributed to this drug have usually been minimal and completely reversible. This is a report of four patients in whom acute renal failure developed during treatment with sodium colistimethate (Coly-Mycin Injectable) (Table).
Report of Cases
Case 1 (Fig 1).
—B.I., a 75-year-old obese woman, was admitted to Presbyterian-St. Luke's Hospital for treatment of a fracture of the femur. On admission, the urinalysis was normal and the blood urea nitrogen (BUN) was 9 mg/100 ml. On the third hospital day, the head of the femur was replaced by a prosthesis. Low-grade fever was noted during the postoperative period. A small diffuse opacity of the right middle lobe of the lung was seen on
ELWOOD CM, LUCAS GD, MUEHRCKE RC. Acute Renal Failure Associated With Sodium Colistimethate Treatment. Arch Intern Med. 1966;118(4):326–334. doi:10.1001/archinte.1966.00290160026006
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