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January 1967

Inhalation of Oxygen and Carbon Dioxide Gas: Effect on Composition of Cerebral Venous Blood

Author Affiliations


From the Department of Neurology, Wayne State University, Detroit General Hospital, the Wayne Center for Cerebrovascular Research, Harper Hospital, Detroit, and the Department of Internal Medicine, Keio University, Tokyo, Japan. Dr. Gotoh is presently with the Cerebral Blood Flow Laboratory, Keio University, Tokyo. Dr. Takagi is a Fellow of the Michigan Heart Association.

Arch Intern Med. 1967;119(1):4-15. doi:10.1001/archinte.1967.00290190052002

INHALATION of either carbon dioxide gas mixtures or 100% oxygen are widely used therapeutically in cerebrovascular disease and conditions causing cerebral anoxia. There is little or no data in man concerning any improvement of oxygen available to the brain resulting from this treatment, although certain drugs are known to increase oxygen available to ischemic brain.1,2

Techniques for monitoring cerebral blood, Po2, Pco2, and pH now permit recording any changes in the composition of the cerebral venous blood during inhalation of oxygen and carbon dioxide gas mixtures. The present communication describes the effects of inhalation of 100% O2, 5% CO2 plus O2, and 5% CO2 plus air on arterial and jugular venous Po2, Pco2, and pH in a group of volunteer subjects with cerebrovascular disease and other disorders.

Material and Methods 

Case Material.  —Twenty-six volunteers with various neurological disorders were studied. The age of the subjects ranged from 13 to 81

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