THE ABILITY of antacids to control ulcer pain is well recognized by patients and their physicians. It is assumed by nearly all physicians that these compounds promote ulcer healing despite the absence of controlled studies to document this assumption. Lacking such studies, physicians have turned to observations made in vivo or in vitro of the effects of these substances on the acidity and peptic activity of the gastric content. Experiments with a wide variety of compounds under an equally wide variety of conditions have produced contradictory results as to the duration and extent of antacid action. In fasting patients Grossman1 found that calcium carbonate exerted an effect in vivo for 40 minutes and that aluminum hydroxide was active for 25 minutes. Fordtran and Collyns2 found that antacids given one hour after a meal exerted an effect for at least three hours whereas antacids given in the fasting state
Morrissey JF, Honda T, Tanaka Y, Perna G. Gastric Mucosal Coating and Gastric Emptying Time of Antacids: A Gastrocamera Study. Arch Intern Med. 1967;119(5):510–517. doi:10.1001/archinte.1967.00290230148006
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