[Skip to Navigation]
May 1967

Histoplasma Endocarditis: Case Report and Review of the Literature

Author Affiliations


From the Medical Service, US Public Health Service Hospital, Baltimore.

Arch Intern Med. 1967;119(5):527-531. doi:10.1001/archinte.1967.00290230165009

HISTOPLASMOSIS as a cause of endocarditis is very uncommon. A thorough search of the literature has revealed only 16 previously reported cases. In view of the rarity of this condition, the difficulty which may be encountered in isolating the organism, and the availability of effective treatment which may arrest the disease, it was felt worthwhile to report the following case and to review the pertinent literature.

Report of Case  A 37-year-old white man entered the US Public Health Service Hospital, Baltimore, on July 31, 1964, because of chills, fever, and transient hemiparesis of the left side. He had had rheumatic fever at age 14, and, subsequently, heart murmurs were noted. Except for one mild episode of hemoptysis and occasional fatigue, he was asymptomatic and able to perform arduous work. Cardiac catheterization in January 1964 revealed predominant mitral stenosis with mitral insufficiency and mild aortic insufficiency. Because of minimal symptomatology,