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June 1967

Split Renal Function Studies in Hypertension

Author Affiliations

Ann Arbor, Mich

From the departments of internal medicine and surgery, University of Michigan Medical Center, Ann Arbor. Dr. Stewart is presently at the Cleveland Clinic.

Arch Intern Med. 1967;119(6):588-592. doi:10.1001/archinte.1967.00290240110008

Following the observation of split renal function studies by White in 1950,1 later modified as a diagnostic test for renovascular hypertension by Howard et al in 1954,2 it seemed possible that split renal function studies might be relied upon to provide a basis for the identification of patients with hypertension resulting from a diminished blood flow to one kidney. In 1957, Conner and associates3 reported that in cases of unilateral renovascular disease the blood pressure improved after surgery only when the preoperative test had shown a diminished urine flow and sodium concentration on the involved side.

A number of methods have subsequently been used to improve the performance or interpretation of split renal function tests, namely those of Rapoport in 1960,4 Stamey in 1961,5 and Birchall et al in 1962.6 It is apparent from the number of tests which have been introduced as well as from published reports,7-10 that no

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