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July 1967

The Liver in Thyrotoxicosis

Author Affiliations

Santiago, Chile

From the departments of medicine and pathology, University of Chile and Hospital San Borja, Santiago.

Arch Intern Med. 1967;120(1):25-32. doi:10.1001/archinte.1967.00300010027005

Liver damage in hyperthyroidism has been repeatedly described in various papers during the last century1, but its frequency and extent are controversial. While marked hepatic anatomical changes were mentioned very often in the initial reports,2-4 two more recent communications hold the opposite view.5,6

The present study was undertaken as a result of these discrepancies, and an attempt is made to explain previously conflicting evidence analyzing our results according to Albot's investigations on liver histology.7

Material and Method  This study includes 23 patients who were divided into two groups. The first group is made up of 15 patients with hyperthyroidism, and the other, which serves as control group, comprises eight thyroid patients without thyrotoxicosis but with miscellaneous thyroid disorders (three with nodular goiters, one with a diffuse goiter, two with thyroiditis, and two with myxedema).Thyroid function was tested by the basal metabolic rate, protein-bound iodine,8

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