[Skip to Navigation]
July 1967

Progressive Hepatic Failure: Its Association With Undifferentiated Renal Tumor

Author Affiliations

Rochester, Minn

From the Mayo Clinic and Mayo Foundation, Gastroenterology Unit (Dr. Summerskill) and Section of Surgical Research (Dr. Shorter).

Arch Intern Med. 1967;120(1):81-84. doi:10.1001/archinte.1967.00300010083015

HEPATOSPLENOMEGALY and abnormal hepatic function may develop in patients with hypernephroma in the absence of any characteristic pathologic lesion in the liver; these changes may revert to normal when the renal tumor is removed.1-4 The present report draws attention to the findings in a patient with both clinical and biochemical abnormalities of liver function which were associated with an apparently different histologic type of primary renal tumor. At autopsy, a localized spindle-celled tumor (considered to be a sarcoma) of the kidney was found, but no specific morphologic changes in the hepatic parenchyma or hepatic vessels were present to account for the features of hepatic failure observed in life.

Report of a Case  A 59-year-old white man in good general health had experienced fatigue and anorexia in December 1959. There was no previous or familial history of disease of the liver or kidneys, but during the preceding five years

Add or change institution