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July 1967

Nephrotic Syndrome With Inferior Vena Cava Stenosis

Author Affiliations


From the Sinai Hospital of Detroit.

Arch Intern Med. 1967;120(1):94-98. doi:10.1001/archinte.1967.00300010096018

THE NEPHROTIC syndrome secondary to thrombosis of the inferior vena cava or renal veins or both, was first recognized and reported by Derow in 1939.1 Pollak subsequently reported 13 cases with renal vein thrombosis.2 Membranous obliteration of the hepatic portion of the inferior vena cava has been implicated in the etiology of the nephrotic syndrome,3 and still other cases secondary to inferior vena cava thrombosis have been reported by Missal4 and Baird.5

We recently encountered a patient with intermittent nephrotic syndrome associated with partial obstruction of the inferior vena cava by extrinsic compressive bands at the diaphragmatic hiatus. Diagnosis was delayed because the nephrotic syndrome has not been reported to occur with incomplete obstruction of renal venous flow.

Report of a Case  The patient (Sinai No. 12-07-19) was relatively well until 1957 when, at the age of 65, she developed pedal edema and mild dyspnea