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August 1967

Primary Macrocryogelglobulinemia: Remission With Adrenal Corticosteroid Therapy

Arch Intern Med. 1967;120(2):234-238. doi:10.1001/archinte.1967.00300020106015

PRIMARY macroglobulinemia is a systemic disease of many manifestations.1 One of the common complications of the disease is a syndrome consisting of bleeding and ocular and neurologic disorders attributable to hyperviscosity of the blood. The syndrome can be fatal, but with control of the serum macroglobulin level and the hyperviscosity many of the patients show striking clinical improvement.2,3

This report describes a case of macroglobulinemia in which an extraordinary increase in the viscosity of the plasma was associated with a macroglobulin that had a propensity for gelling at room temperature. A marked reduction in the viscosity of the patient's plasma and a clinical remission followed administration of adrenal corticosteroids.

Report of a Case  A 70-year-old man was first admitted to the Santa Clara County Hospital on Jan 1, 1962, because of severe pain after being struck on the chest by a falling chair. Two years earlier the patient