[Skip to Navigation]
September 1967

Hematuria and A-D Hemoglobinopathy

Author Affiliations

Durham, NC

From the Department of Medicine, Division of Nephrology, Duke University Medical Center and Durham Veterans Administration Hospital, Durham, NC.

Arch Intern Med. 1967;120(3):337-340. doi:10.1001/archinte.1967.00300030079015

THE differential diagnosis of hematuria is lengthy and well-described.1 Even with further advances in diagnostic techniques, a significant number of patients with hematuria, despite thorough and repeated evaluation, exhibit no demonstrable pathology to explain this finding and are usually classified as having "essential" or "unexplained" hematuria. The important association of sickle cell hemoglobinopathy and hematuria was first described by Goodwin et al in 1950.2 Since that report, a larger number of patients primarily classified as having "essential" hematuria have been diagnosed as having sickle cell disease or trait and hematuria. In addition, hematuria has been described in association with a number of other heterozygous hemoglobin-S combinations.3-6 It is the purpose of this report to describe a patient with A-D hemoglobin and a 13-year history of "essential" hematuria and to emphasize the important laboratory features of this hemoglobinopathy that separates it from the hemoglobin-S syndromes previously reported with