[Skip to Navigation]
September 1967

Autoimmune Hemolytic Anemia, Acute Leukemia, and Carcinoma of the Lung: Sodium Phosphate P 32 Treatment of Polycythemia Vera

Author Affiliations

Bethesda, Md

Arch Intern Med. 1967;120(3):341-344. doi:10.1001/archinte.1967.00300030083016

AUTOIMMUNE hemolytic anemia is not uncommonly associated with malignant reticuloendothelial disease. It has been frequently described in association with the chronic leukemias but rarely occurs in the acute types, and only one patient has been reported to have a concomitant carcinoma.1 Dausset and Colombani2 studied 128 patients with autoimmune hemolytic anemia; none had an underlying carcinoma or acute leukemia.

We wish to present an unusual patient with polycythemia vera who was treated with sodium phosphate P 32 and developed acute myelogenous leukemia and adenocarcinoma of the lung complicated by an autoimmune hemolytic anemia.

Report of a Case  A 62-year-old white woman (04-92-98), entered the National Institutes of Health Clinical Center for the first time in May 1963, with a four-month history of night sweats, occipital headaches, and intense pruritis after bathing. Physical examination revealed a ruddy cyanosis; a blood pressure of 165/95 mm Hg; pulse rate, 100