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September 1967

Therapy of Bacterial Endocarditis in Penicillin-Hypersensitive Patients: Two Cases Treated With Lincomycin and Streptomycin

Author Affiliations


From the Infectious Disease Division of the Department of Medicine of Marquette University School of Medicine and Milwaukee County General Hospital, and the Department of Medicine of Mount Sinai Hospital, Milwaukee.

Arch Intern Med. 1967;120(3):361-364. doi:10.1001/archinte.1967.00300030103021

THE PRESENT methods of treatment of subacute bacterial endocarditis due to α- or γ-streptococci in penicillin-hypersensitive patients are the following: penicillin given cautiously in the hope that the history is in error or that there will not be a repeat occurrence of hypersensitivity; cortisone or one of its derivatives given concurrently with penicillin; desensitization to penicillin; ristocetin or cephalothin given instead of penicillin.1-4

The two cases detailed below suggest that therapy with the combination of lincomycin and streptomycin is another method of therapy for use in penicillinhypersensitive patients who have endocarditis due to α- or γ-streptococci.5-6

Report of Cases 

Case 1.  —The patient was a 55-year-old white man admitted to Mount Sinai Hospital on Dec 20, 1965, because of chills and fever of one month's duration. He had been known to have rheumatic heart disease with mitral insufficiency since 1953 and had been taking digitalis since 1955. Pertinent

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