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October 1, 1967

Hypoparathyroidism: Clinical Observations in 34 Patients

Author Affiliations

Brooklyn, NY

From the departments of medicine and ophthalmology, State University-Kings County Medical Center and the Downstate Medical Center, State University of New York, Brooklyn. Dr. Dimich is now at the Sloan-Kettering Institute for Cancer Research, New York.

Arch Intern Med. 1967;120(4):449-458. doi:10.1001/archinte.1967.04410010063009

ALTHOUGH hypoparathyroidism is an uncommon disease, numerous reviews of postoperative, idiopathic, and pseudohypoparathyroidism are available.1-8 The majority of these reports are reviews of the literature, since few institutions have accumulated a large number of patients with hypoparathyroidism. The purpose of the present communication is to report our experience with 34 patients with hypoparathyroidism observed during a recent ten-year period.

Method of Study  The records of all patients with a diagnosis of hypoparathyroidism during the period 1954 to 1964 were reviewed. Thirty-four patients fulfilling the following criteria were admitted to the study:

  1. The presence of hypocalcemia not due to renal insufficiency, gastrointestinal malabsorption, acute pancreatitis, or osteoblastic metastases. In postthyroidectomy patients, hypocalcemia was required to be present at least 18 months postoperatively to eliminate cases of transient hypoparathyroidism.

  2. The presence of a normal or elevated serum concentration of inorganic phosphorus. This criterion was required to eliminate cases of gastrointestinal malabsorption, pancreatitis