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October 1, 1967

Chronic Alcoholism With Pancreatitis, Cirrhosis, and Hyperlipemia: Zieve's Syndrome, Report of a Case Studied at Necropsy

Author Affiliations


From the Department of Pathology, Kuakini Hospital, Honolulu.

Arch Intern Med. 1967;120(4):465-471. doi:10.1001/archinte.1967.04410010079011

IN 1958, Zieve described a syndrome consisting of transient hyperlipemia, jaundice and hemolytic anemia occurring in patients with alcoholic fatty liver and cirrhosis.1 Other observers have collected examples of this condition. We have recently completed a postmortem study of a patient who died during such an episode. Inasmuch as this condition is usually transient and nonfatal, the necropsy examination merits a detailed report, especially since it revealed changes which have not been encountered in any other disease.

Report of a Case  This man of Japanese ancestry was first admitted to the hospital on Oct 29, 1958, at the age of 46 years. He had diarrhea for one week, Pain in the left lower portion of the chest, and mild cough. He had from eight to 12 watery, dark brown bowel movements a day. The chest pain and cough subsided two days after onset. He was a carpenter, smoked three-fourths pack

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