[Skip to Navigation]
October 1, 1967

Syndromes of Disseminated Intravascular Coagulation: With Special Reference to Shock and Hemorrhage.

Author Affiliations

Madison, Wis

Arch Intern Med. 1967;120(4):514. doi:10.1001/archinte.1967.04410010128021

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This book contains four sections of 35 chapters devoted to a comprehensive review of the author's research and experience since 1950. Original investigation was stimulated by four clinical cases with a common triad of shock, bleeding tendency, and acute renal failure. This was identified as the syndrome of acute disseminated intravascular coagulation (DIC).

Diagnosis is based on histologic evidence of capillary thrombi and clinical observation of sudden hypotensive shock and a bleeding tendency. The coagulopathy involves fibrinogen (plus any or all of the 12 coagulation factors), platelets, and activated endogenous heparin and fibrinolysins. The inciting clinical conditions are many; they include trauma, burns, transfusion reaction, acute organ failure, hemolytic disorders, complications of late pregnancy, extracorporeal circulation, and others.

Etiologic studies are based on observations in dogs and are accompanied by excellent photomicrographs in chapters 2 and 3. The coagulopathy is postulated to be a three-stage mechanism involving formation of a

First Page Preview View Large
First page PDF preview
First page PDF preview
Add or change institution