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Study Initiated.—The Laboratory of Clinical Investigations, National Institute of Allergy and Infectious Diseases, National Institutes of Health, has initiated a study of infectious mononucleosis, infectious lymphocytosis, and related diseases. Patients with acute infectious mononucleosis-like illnesses with clinical manifestations of fever, malaise, lymphadenopathy, pharyngitis, and peripheral lymphocytosis with atypical forms are being sought.Areas of investigation are the virologic, hematologic, and immunologic manifestations of these disease syndromes: Virologic studies—Attempts will be made to demonstrate or isolate an infectious agent with a variety of newly developed tissue culture techniques. Hematologic studies—The function of the atypical lymphocyte will be studied in terms of DNA, RNA, and specific immunoglobulin synthesis. Immunologic studies—Origin and classification of the heterophil antibody, acute phase proteins, and serum immunoglobulins, as well as the production of the specific agglutinins associated with acute hemolytic anemia will be studied.Upon completion of their studies the patients are returned to the care