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December 1967

Hemochromatosis in Association With Hereditary Spherocytosis

Arch Intern Med. 1967;120(6):701-707. doi:10.1001/archinte.1967.00300050057009

ALTHOUGH hemochromatosis has been described in association with a number of chronic refractory hemolytic anemias, it usually occurs in patients who have received multiple blood transfusions. Cases of hemolytic anemia are recorded where massive iron overload occurs without the addition of parenteral iron. There is a single case report of hemochromatosis associated with congenital spherocytosis in a man who took 120 mg of elemental iron daily for 12 years.1 The present paper describes the case of a young woman with hereditary spherocytosis and hemochromatosis, with no history of heavy prolonged iron intake. This woman may represent the third recorded example of an association which we believe has been reported only once previously in a male set of identical twins.2

Report of a Case  In July 1962, a 29-year-old housewife was admitted to the hospital with precordial chest pain, pleurisy, polyarthralgia, dyspnea, and bilateral conjunctivitis. A fever lasted