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May 1968

Herpes Zoster in a Patient With Hodgkin's DiseaseTreatment With Idoxuridine

Arch Intern Med. 1968;121(5):458-462. doi:10.1001/archinte.1968.03640050068014

The development of herpes zoster, particularly the disseminated form, in a patient with Hodgkin's Disease is generally a cause of concern, for this infection is associated with increased morbidity and mortality.1 Until recently no satisfactory specific treatment had been described. In 1965, Calabresi2 suggested the systemic use of idoxuridine (IUDR) in the therapy of disseminated zoster infections. The rationale for the use of IUDR is the fact that herpes zoster is a deoxyribonucleic acid containing virus and IUDR has been shown to effectively inhibit the replication of several DNA containing viruses.3 This compound, a thymidine antimetabolite, had been found to be effective in the treatment of ophthalmic herpes simplex infections.4 We have recently had the opportunity to treat a patient with stage IV Hodgkin's disease and disseminated herpes zoster with this agent.

Patient Summary  A 34-year-old white Airman originally presented in March 1955 with a right

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