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March 1969

Grundlagen der Pharmakokinetik, ed 2.

Arch Intern Med. 1969;123(3):353. doi:10.1001/archinte.1969.00300130135025

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"Pharmakokinetiks" is the author's neologism for quantitative interactions of living organisms and drugs. Consequently, this book analyzes the human physiologic processes affecting absorption, diffusion, distribution, and elimination of drugs. Factors influencing blood concentrations of medications and renal (and other) clearances are discussed in detail. Great use is made of graphs and mathematic formulae.

The first edition of this book was published in 1953; this edition is both an enlargement and revision. Believing that analogue computers have facilitated understanding of metabolic mechanisms, Dost devotes one chapter to a discussion of the principles and uses of computers in pharmacophysiology.

The extraordinarily detailed table of contents (eight pages), in addition to a good index, should help those whose primary language is not German. The author's style is clear, but I think that readers with only moderate facility with German may have difficulty. However, even such readers should derive considerable information from the abundant,

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