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June 1969

Calcium Pyrophosphate Dihydrate Crystal Deposition Disease

Author Affiliations


From the Arthritis and Connective Tissue Section of the Evans Department of Clinical Research, University Hospital,; and the Department of Medicine, Boston University School of Medicine, Boston University Medical Center.

Arch Intern Med. 1969;123(6):636-644. doi:10.1001/archinte.1969.00300160026005

Eighteen patients had definite calcium pyrophosphate dihydrate crystal deposition disease (pseudogout) as shown by clinical and roentgenographic findings plus results of synovial fluid analyses. Seventy-two percent of the patients had diabetes mellitus and 33% had hypertension. Hyperuricemia was an uncommon finding except in association with azotemia and in one patient who also had gout. All patients had typical calcium pyrophosphate crystals in the synovial fluid and one patient also had an unidentified crystal. The character of the synovial fluid appeared to relate to the duration of the acute attack. The fluid was generally of an inflammatory type. Chondrocalcinosis was present roentgenographically in all joints where crystals were found and often in several other joints. Simple therapeutic measures (arthrocenteses) usually relieved the acute articular symptoms.