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June 1969

Treatment of AGL

Arch Intern Med. 1969;123(6):725-726. doi:10.1001/archinte.1969.00300160115021

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To the Editor.  —As a not-so-innocent bystander, I should like to enter into the Crosby-Lee debate on the "Treatment of AGL" (Arch Intern Med123:205-207 [Feb] 1969). This is to some extent a debate between the proponents of the "protocol" method of chemotherapy of leukemia (exemplified by Lee), and those who maintain a solo or non-protocol approach (Crosby) to the agonizing problem of whether or how to treat an adult with acute leukemia. I have been intimately connected with both schools, first in Boston as Crosby's predecessor, and more recently in New York at the Mount Sinai Hospital, where protocol therapy under the aegis of Acute Leukemia Cooperative Chemotherapy Group B holds sway.Lee's data, based on a large number of treated cases, pitted against some rather general statements of Crosby's and the data and the philosophy do not always jibe. Granted that remissions, even to the extent of

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