A 38-year-old woman with aortic arch syndrome (pulseless disease), had received an excessive amount of radiation to her neck in early childhood. The roentgenographic, surgical, and pathologic changes found were occlusions and severe luminal narrowing of the involved arteries of the upper part of the thorax and marked artherosclerotic changes with calcification of the vessel walls. These findings were sharply restricted to the field of radiation. This communication describes a previously unreported cause of aortic arch syndrome and well demonstrates the possible toxic effects of large doses of radiation, particularly when administered to the young.
Rotman M, Seidenberg B, Rubin I, Botstein C, Bosniak M. Aortic Arch Syndrome Secondary to Radiation in Childhood. Arch Intern Med. 1969;124(1):87–90. doi:10.1001/archinte.1969.00300170089017