Severe postoperative hematuria and other hemorrhagic symptoms developed in six patients following transurethral resection of the prostate gland for benign adenoma. Disseminated intravascular coagulation appeared to be responsible for the syndrome in all patients. The laboratory data which supported this diagnosis were thrombocytopenia, marked shedding of red blood cells from the blood clot, decreased concentration of coagulation factor I (fibrinogen), high titer of fibrin degradation products in the serum, decreased one-stage prothrombin activity, and decreased concentrations of multiple clotting factors, particularly factors V and VIII. There was no evidence of generalized fibrinolysis. Significant etiologic factors were thought to be the extent and duration of the operation, the use of water for irrigation, and the presence of shock. Treatment with fibrinogen and heparin sodium appeared to be beneficial in those who survived the immediate postoperative period.
Friedman NJ, Hoag MS, Robinson AJ, Aggeler PM. Hemorrhagic Syndrome Following Transurethral Prostatic Resection for Benign Adenoma. Arch Intern Med. 1969;124(3):341–349. doi:10.1001/archinte.1969.00300190081013
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