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September 1969

Hemodynamic Responses to Chlorpromazine in Patients in Shock

Author Affiliations


From the Hektoen Institute for Medical Research, Cook County Hospital; and the departments of medicine, University of Illinois College of Medicine (Drs. Loeb, Pietras, and Gunnar) and Loyola University Stritch School of Medicine, Chicago (Dr. Tobin). Dr. Loeb was a research fellow of the Chicago Heart Association and was supported by grant F67-1. Dr. Ninos was a fellow in cardiology at Cook County Hospital.

Arch Intern Med. 1969;124(3):354-358. doi:10.1001/archinte.1969.00300190094015

Hemodynamic measurements were obtained from 18 patients in shock before and after administration of chlorpromazine. Mean arterial pressure fell in all but one patient due to a reduction in systemic vascular resistance. Improved cardiac output occurred in nine patients, who, when compared to the others, had higher arterial and central venous pressures, higher vascular resistances, and had shown a poorer response to plasma volume expansion. These observations suggest that chlorpromazine will reduce vascular resistance in most patients in shock, but will not improve cardiac output if central aortic pressure is low or previous fluid replacement has been inadequate.