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September 1969

Methodenlehre der Therapeutischklinischen Forschung, ed 4,

Author Affiliations


Arch Intern Med. 1969;124(3):388. doi:10.1001/archinte.1969.00300190128027

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This edition is seven times as long as the first, which the late Professor Martini published in 1932; this attests to the recent advances in methodology of research in clinical therapeutics and the increased recognition of the importance of such research. The authors are professors of internal medicine at the University of Bonn.

General principles of clinical measurement and basic statistical methods are presented in the first segment, and appropriate tables are appended. The larger segment gives applications of these principles to the evaluation of treatment of various diseases and symptoms. Some useful examples of therapeutic record forms and FORTRAN (Formula Translating System) computer programs are included. Although an international bibliography is drawn upon, the authors fail to cite some of the most instructive therapeutic studies, either as exemplary or for methodologic criticism. For example, the section on tuberculosis lacks any mention of the US Veterans Administration-Armed Forces cooperative studies

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