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February 1970

Deficiency Rickets in New York: Dissociation Between Urinary Hydroxyproline and Glycylproline With Treatment

Author Affiliations


From the Hospital for Special Surgery and the Department of Medicine, Cornell University Medical College, New York. Dr. Saville is now with the Department of Medicine, Creighton University, Omaha; and Dr. Alderman is with the Department of Medicine, Lincoln Hospital, Bronx, NY.

Arch Intern Med. 1970;125(2):341-343. doi:10.1001/archinte.1970.00310020147023

Deficiency of vitamin D is probably the least common cause of rickets in western Europe and the United States. Recently, several patients have been reported from Scotland,1 but we are not aware of any that have been reported from New York city in the last ten years. Furthermore, we have not had a single patient in the Metabolic Bone Disease Clinic at the Hospital for Special Surgery since this specialty clinic was opened ten years ago in New York.

In this communication, we are briefly recording an instance of rickets due to vitamin D deficiency. We have taken the opportunity to measure urinary hydroxyproline (hypro) as well as glycylproline (glypro) before and during medication with physiological doses of vitamin D.

Patient Summary  The patient was a 23-month-old Negro boy who presented with bowlegs. The product of a full-term pregnancy and normal delivery, with a birth weight of 2,437 gm