Constitutional reaction to a single sting of an hymenopteron occurred in 400 unselected patients. The average patient had a family history of allergy and a personal history of previous insect stings. Eight percent of patients, however, had no previous warning of anaphylaxis, and 6% received intravenous stings. Epinephrine hydrochloride was the drug of choice in the crisis. Of the patients who had received hyposensitizing treatments, 88% were protected against adverse reactions to subsequent stings.
Brown H, Bernton HS. Allergy to the HymenopteraV. Clinical Study of 400 Patients. Arch Intern Med. 1970;125(4):665–669. doi:10.1001/archinte.1970.00310040089010
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