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July 1970

Interferon and Interferon Inducers in the Treatment of Malignancies

Arch Intern Med. 1970;126(1):78-83. doi:10.1001/archinte.1970.00310070080007

Several laboratories have reported that viral interference,1 interferon,2 and interferon inducers 3,4 can inhibit the growth of oncogenic viruses in tissue culture,5 and can alter the course of murine leukemias in animals.6,7 It has also been shown that the double-stranded RNA, polyriboinosinic: polyribocytidylic acid (poly I:C), which among other things is a good interferon inducer,8 inhibits the growth of a large variety of tumors in animals.9-11 Finally, exogenous interferon also inhibits some transplanted tumors that were induced originally by chemical carcinogenesis and not by viruses.12 The purpose of this review is to consider some of the factors involved in these tumor inhibitions. The variety of tumors inhibited by poly I:C is indicated in Table 1. In addition to those shown, carcinogenesis by dimethylbenzanthracine (DMBA) plus croton oil or DMBA alone is strongly inhibited by suitable administration of poly I:C.13

For reasons of convenience further discussion will center about the various

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