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July 1970

Double-Stranded RNAs (Poly I:C) in the Prevention of Viral Infections

Arch Intern Med. 1970;126(1):109-124. doi:10.1001/archinte.1970.00310070111010

The effective control of viral diseases is a difficult problem and necessitates the exercise of opportunism to explore and utilize all possible approaches. Certain of the viruses for which there is a single or few serotypes lend themselves well to control by vaccines as, eg, poliomyelitis, measles, mumps, rubella, yellow fever, influenza, and smallpox. Other viruses, such as the rhinoviruses which cause the common cold, and the enteroviruses which cause systemic, respiratory, and enteric diseases, are of such diverse antigenic composition as to be unlikely of control by vaccines within the foreseeable future. The interferon mechanism has excited great interest with respect to control of these viruses, especially since the process has the outstanding characteristic of broad-spectrum of activity against essentially all viruses. The promise of the chemical approach (ie, chemoprophylaxis and chemotherapy) is still to be tested, but this avenue is likely to be pursued with increasing vigor as