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August 1970

Down's Syndrome: Mongolism and Its Management.

Author Affiliations

Cambridge, Mass

Arch Intern Med. 1970;126(2):338. doi:10.1001/archinte.1970.00310080144032

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The discovery by Lejeune in 1959 that there is an extra chromosome in the G group of most patients with Down's syndrome created a revolution in understanding and a revival of research into this common and devastating disorder. Now that this dramatic cytological finding has been exploited for ten years Benda's monograph comes at a time when old and newer information can be consolidated. This is a revised edition of The Child With Mongolism, which was published in 1960, and that volume in turn was the sequel to Mongolism and Cretinism, which first appeared in 1946. The present edition appears only a short time after Penrose and Smith's monograph on Down's syndrome, which marked the 100th anniversary of Langdon Down's original description in 1866 of the disorder which now bears his name.

The strength of this book is in clinical description and in gross and microscopic anatomy. These are presented